{"id":116,"date":"2024-11-03T23:14:02","date_gmt":"2024-11-03T23:14:02","guid":{"rendered":"https:\/\/ectocellect.com\/?page_id=116"},"modified":"2026-04-15T10:39:55","modified_gmt":"2026-04-15T10:39:55","slug":"receptor-discovery-and-deorphanization","status":"publish","type":"page","link":"https:\/\/ectocellect.com\/?page_id=116","title":{"rendered":"Receptor discovery and deorphanisation"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Header & Video” _builder_version=”4.27.4″ _module_preset=”f6f78c45-59f4-4276-80e0-32269ad226de” background_color=”#EBEBEB” custom_margin=”||||false|false” locked=”off” collapsed=”off” global_colors_info=”{%22gcid-1f1bf5fb-a99d-4acc-8d9e-ddac074c158c%22:%91%22background_color_gradient_stops%22,%22background_color_gradient_stops%22,%22background_color_gradient_stops%22,%22background_color_gradient_stops%22%93,%22gcid-a78660e1-cfc7-4771-a566-6834d6a7f06a%22:%91%22background_color_gradient_stops%22,%22background_color_gradient_stops%22,%22background_color_gradient_stops%22,%22background_color_gradient_stops%22%93,%22gcid-24b0db87-dafa-47d9-995f-b90181e18c52%22:%91%22background_color_gradient_stops%22,%22background_color_gradient_stops%22,%22background_color_gradient_stops%22,%22background_color_gradient_stops%22%93}”][et_pb_row _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.25.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”Receptor Discovery and Deorphanisation” _builder_version=”4.27.4″ _module_preset=”67ae7bfb-dee9-4049-bfee-5a2faf8e791d” title_text_color=”#1A283B” custom_margin=”||10px||false|false” global_colors_info=”{}”][\/et_pb_heading][et_pb_blurb title=”A trusted platform to deorphanise ligands and receptors” use_icon=”on” font_icon=”R||divi||400″ _builder_version=”4.27.4″ _module_preset=”d248538e-e1ae-493e-b38e-1f4c5e8a6e82″ header_font=”Urbanist|–et_global_heading_font_weight|||||||” header_text_color=”#1A283B” background_layout=”dark” custom_padding=”|||30px|false|false” header_font_size_tablet=”” header_font_size_phone=”” header_font_size_last_edited=”on|phone” global_colors_info=”{%22gcid-1f1b4e15-7cc6-4e13-8154-74d77a956460%22:%91%22icon_color%22%93}”][\/et_pb_blurb][et_pb_blurb title=”Identify novel receptors for orphan ligands” use_icon=”on” font_icon=”R||divi||400″ _builder_version=”4.27.4″ _module_preset=”d248538e-e1ae-493e-b38e-1f4c5e8a6e82″ header_font=”Urbanist|–et_global_heading_font_weight|||||||” header_text_color=”#1A283B” background_layout=”dark” custom_padding=”|||30px|false|false” header_font_size_tablet=”” header_font_size_phone=”” header_font_size_last_edited=”on|phone” global_colors_info=”{%22gcid-1f1b4e15-7cc6-4e13-8154-74d77a956460%22:%91%22icon_color%22%93}”][\/et_pb_blurb][et_pb_blurb title=”Host-pathogen interactions including virus receptors, microbiome, and parasites” use_icon=”on” font_icon=”R||divi||400″ _builder_version=”4.27.4″ _module_preset=”d248538e-e1ae-493e-b38e-1f4c5e8a6e82″ header_font=”Urbanist|–et_global_heading_font_weight|||||||” header_text_color=”#1A283B” background_layout=”dark” custom_padding=”|||30px|false|false” header_font_size_tablet=”” header_font_size_phone=”” header_font_size_last_edited=”on|phone” global_colors_info=”{%22gcid-1f1b4e15-7cc6-4e13-8154-74d77a956460%22:%91%22icon_color%22%93}”][\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”R||divi||400″ _builder_version=”4.27.4″ _module_preset=”d248538e-e1ae-493e-b38e-1f4c5e8a6e82″ header_font=”Urbanist|–et_global_heading_font_weight|||||||” body_font=”Urbanist|–et_global_body_font_weight|||||||” body_text_color=”#1A283B” body_font_size=”24px” background_layout=”dark” custom_padding=”|||30px|false|false” header_font_size_tablet=”” header_font_size_phone=”” header_font_size_last_edited=”on|phone” global_colors_info=”{%22gcid-1f1b4e15-7cc6-4e13-8154-74d77a956460%22:%91%22icon_color%22%93}”]<\/p>\n

Ectocellect receptor array detects even very weak (K<\/i>D<\/span><\/sub>s ~ 10\u00b5M<\/span>) with low false positive and false negative rates
<\/span><\/h3>\n

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”#FFFFFF” global_colors_info=”{}”][et_pb_row column_structure=”1_3,2_3″ disabled_on=”on|on|on” _builder_version=”4.27.4″ _module_preset=”default” background_color=”#FFFFFF” width=”100%” max_width=”1500px” custom_padding=”0px|0px|0px|0px|false|false” disabled=”on” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/ectocellect.com\/wp-content\/uploads\/2025\/11\/Receptor-deorphanisation-case-study-enlarged.png” title_text=”Receptor-deorphanisation-case-study enlarged” _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”|-54px||6px||” custom_padding=”|0px||0px||” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”Deorphanisation case study” _builder_version=”4.27.4″ _module_preset=”af177d2f-91a8-4f2e-87ba-17a4fb97b9b4″ title_font=”Urbanist|600|||||||” title_text_align=”left” title_text_color=”#1a283b” title_font_size=”25px” custom_margin=”||10px||false|false” global_colors_info=”{}”][\/et_pb_heading][et_pb_text _builder_version=”4.27.4″ _module_preset=”707627bc-2994-4635-8ae1-9f0e8da7cbac” custom_margin=”||17px||false|false” global_colors_info=”{}”]<\/p>\n

The Ectocellect human receptor array was used to identify direct interactions with human host receptors for a parasite immunoregulatory ligand. Specificity is demonstrated here as the ligand identified five different members of the same human receptor family.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”#FFFFFF” width=”100%” max_width=”1500px” custom_padding=”0px|0px|0px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”|||30px|false|false” global_colors_info=”{}”][et_pb_image src=”https:\/\/ectocellect.com\/wp-content\/uploads\/2025\/11\/thumbnail_Parasite_case_study.jpg” title_text=”thumbnail_Parasite_case_study” _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”|-54px||6px||” custom_padding=”|0px||0px||” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”|30px|||false|false” global_colors_info=”{}”][et_pb_heading title=”Deorphanisation case study” _builder_version=”4.27.4″ _module_preset=”af177d2f-91a8-4f2e-87ba-17a4fb97b9b4″ title_font=”Urbanist|600|||||||” title_text_align=”left” title_text_color=”#1a283b” title_font_size=”25px” custom_margin=”||10px||false|false” global_colors_info=”{}”][\/et_pb_heading][et_pb_text _builder_version=”4.27.4″ _module_preset=”707627bc-2994-4635-8ae1-9f0e8da7cbac” custom_margin=”||17px||false|false” global_colors_info=”{}”]<\/p>\n

The Ectocellect human receptor array was used to identify direct interactions with human host receptors for a parasite immunoregulatory ligand. Specificity is demonstrated here as the ligand identified five different members of the same human receptor family.<\/span><\/p>\n

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Cost effectively test binding specificity of antibodies and AI-designed binders.<\/span><\/p>\n

[\/et_pb_text][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6Ijk3In19@” button_text=”Learn More” disabled_on=”on|on|on” _builder_version=”4.27.4″ _dynamic_attributes=”button_url” _module_preset=”dfb0e518-2979-485c-8b06-b5f2606a4bbd” custom_margin=”18px|||||” disabled=”on” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.25.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/ectocellect.com\/wp-content\/uploads\/2025\/10\/Application-2-1.jpg” title_text=”Application-2″ url=”https:\/\/ectocellect.com\/?page_id=125″ _builder_version=”4.27.4″ _module_preset=”922a35c2-e5b8-45c9-b5a1-02911cedc9fe” min_height=”155.8px” custom_margin=”||||false|false” global_colors_info=”{}”][\/et_pb_image][et_pb_heading title=”Antibody target deconvolution ” _builder_version=”4.27.4″ _module_preset=”592518e2-95a0-450f-8009-699fb1693990″ custom_margin=”||0px||false|false” global_colors_info=”{}”][\/et_pb_heading][et_pb_text _builder_version=”4.27.4″ _module_preset=”707627bc-2994-4635-8ae1-9f0e8da7cbac” custom_margin=”||17px||false|false” global_colors_info=”{}”]<\/p>\n

Identify the targets of functional antibodies of unknown specificity.<\/p>\n

[\/et_pb_text][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjEyNSJ9fQ==@” button_text=”Learn More” disabled_on=”on|on|on” _builder_version=”4.27.4″ _dynamic_attributes=”button_url” _module_preset=”dfb0e518-2979-485c-8b06-b5f2606a4bbd” custom_padding=”14px|50px|14px|40px|true|false” disabled=”on” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.25.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/ectocellect.com\/wp-content\/uploads\/2025\/10\/Autoantibody-target-discovery-1.jpg” title_text=”Autoantibody-target-discovery” url=”https:\/\/ectocellect.com\/?page_id=273″ _builder_version=”4.27.4″ _module_preset=”922a35c2-e5b8-45c9-b5a1-02911cedc9fe” custom_margin=”||||false|false” global_colors_info=”{}”][\/et_pb_image][et_pb_heading title=”Autoantibody target discovery ” _builder_version=”4.27.4″ _module_preset=”592518e2-95a0-450f-8009-699fb1693990″ custom_margin=”||0px||false|false” global_colors_info=”{}”][\/et_pb_heading][et_pb_text _builder_version=”4.27.4″ _module_preset=”707627bc-2994-4635-8ae1-9f0e8da7cbac” custom_margin=”||10px||false|false” custom_padding=”||5px|||” global_colors_info=”{}”]<\/p>\n

Discover the targets of patient autoantibodies<\/p>\n

[\/et_pb_text][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI3MyJ9fQ==@” button_text=”Learn More” disabled_on=”on|on|on” _builder_version=”4.27.4″ _dynamic_attributes=”button_url” _module_preset=”dfb0e518-2979-485c-8b06-b5f2606a4bbd” disabled=”on” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Footer” module_id=”Contact” _builder_version=”4.27.2″ _module_preset=”a41791f7-5e59-44e5-ab7e-f0e840e3570f” saved_tabs=”all” locked=”off” collapsed=”on” global_colors_info=”{}”][et_pb_row _builder_version=”4.25.1″ _module_preset=”default” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.25.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50Ijoic2l0ZV9sb2dvIiwic2V0dGluZ3MiOnt9fQ==@” title_text=”divi-logo-mark-white” 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Ectocellect receptor array detects even very weak (KDs ~ 10\u00b5M) with low false positive and false negative ratesThe Ectocellect human receptor array was used to identify direct interactions with human host receptors for a parasite immunoregulatory ligand. Specificity is demonstrated here as the ligand identified five different members of the same human receptor family.The Ectocellect […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-116","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/ectocellect.com\/index.php?rest_route=\/wp\/v2\/pages\/116","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ectocellect.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ectocellect.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ectocellect.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ectocellect.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=116"}],"version-history":[{"count":40,"href":"https:\/\/ectocellect.com\/index.php?rest_route=\/wp\/v2\/pages\/116\/revisions"}],"predecessor-version":[{"id":453,"href":"https:\/\/ectocellect.com\/index.php?rest_route=\/wp\/v2\/pages\/116\/revisions\/453"}],"wp:attachment":[{"href":"https:\/\/ectocellect.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=116"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}