{"id":97,"date":"2024-11-03T22:56:33","date_gmt":"2024-11-03T22:56:33","guid":{"rendered":"https:\/\/ectocellect.com\/?page_id=97"},"modified":"2026-04-15T10:37:33","modified_gmt":"2026-04-15T10:37:33","slug":"antibody-specificity-and-off-target-testing","status":"publish","type":"page","link":"https:\/\/ectocellect.com\/?page_id=97","title":{"rendered":"Antibody specificity and off-target testing"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Header &#038; Video&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;f6f78c45-59f4-4276-80e0-32269ad226de&#8221; background_color=&#8221;#EBEBEB&#8221; custom_margin=&#8221;||||false|false&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{%22gcid-1f1bf5fb-a99d-4acc-8d9e-ddac074c158c%22:%91%22background_color_gradient_stops%22,%22background_color_gradient_stops%22,%22background_color_gradient_stops%22%93,%22gcid-a78660e1-cfc7-4771-a566-6834d6a7f06a%22:%91%22background_color_gradient_stops%22,%22background_color_gradient_stops%22,%22background_color_gradient_stops%22%93,%22gcid-24b0db87-dafa-47d9-995f-b90181e18c52%22:%91%22background_color_gradient_stops%22,%22background_color_gradient_stops%22,%22background_color_gradient_stops%22%93}&#8221;][et_pb_row _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;Antibody specificity and off-target testing&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;67ae7bfb-dee9-4049-bfee-5a2faf8e791d&#8221; title_text_color=&#8221;#1A283B&#8221; custom_margin=&#8221;||10px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_blurb use_icon=&#8221;on&#8221; font_icon=&#8221;&#x52;||divi||400&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;d248538e-e1ae-493e-b38e-1f4c5e8a6e82&#8243; header_font=&#8221;Urbanist|&#8211;et_global_heading_font_weight|||||||&#8221; header_text_color=&#8221;#1A283B&#8221; body_font=&#8221;Urbanist|500|||||||&#8221; body_text_color=&#8221;#1A283B&#8221; custom_padding=&#8221;|||30px|false|false&#8221; header_font_size_tablet=&#8221;&#8221; header_font_size_phone=&#8221;&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; custom_css_free_form=&#8221;\/* Ensure link color matches and allow underline on hover *\/||.rm-heading a { ||  color: #1a283b; ||  text-decoration: none; ||}||.rm-heading a:hover { ||  text-decoration: underline !important; ||}||||||&#8221; global_colors_info=&#8221;{%22gcid-1f1b4e15-7cc6-4e13-8154-74d77a956460%22:%91%22icon_color%22%93}&#8221;]<\/p>\n<h3 class=\"rm-heading\" style=\"font-family: 'Urbanist',sans-serif; font-weight: 500; font-size: 24px; color: #1a283b; margin: 0;\">Up to a third of all lead candidate antibodies display off-target binding: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11346545\" target=\"_blank\" rel=\"noopener\">Read More<\/a><\/h3>\n<p>[\/et_pb_blurb][et_pb_blurb title=&#8221;De-risk expensive late-stage failures with cost effective early off-target testing during lead selection&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#x52;||divi||400&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;d248538e-e1ae-493e-b38e-1f4c5e8a6e82&#8243; header_font=&#8221;Urbanist|&#8211;et_global_heading_font_weight|||||||&#8221; header_text_color=&#8221;#1A283B&#8221; background_layout=&#8221;dark&#8221; custom_padding=&#8221;|||30px|false|false&#8221; header_font_size_tablet=&#8221;&#8221; header_font_size_phone=&#8221;&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{%22gcid-1f1b4e15-7cc6-4e13-8154-74d77a956460%22:%91%22icon_color%22%93}&#8221;][\/et_pb_blurb][et_pb_blurb title=&#8221;Direct antibody binding is quantified on our receptor arrays &#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#x52;||divi||400&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;d248538e-e1ae-493e-b38e-1f4c5e8a6e82&#8243; header_font=&#8221;Urbanist|&#8211;et_global_heading_font_weight|||||||&#8221; header_text_color=&#8221;#1A283B&#8221; background_layout=&#8221;dark&#8221; custom_padding=&#8221;|||30px|false|false&#8221; header_font_size_tablet=&#8221;&#8221; header_font_size_phone=&#8221;&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{%22gcid-1f1b4e15-7cc6-4e13-8154-74d77a956460%22:%91%22icon_color%22%93}&#8221;][\/et_pb_blurb][et_pb_blurb title=&#8221;Test the binding specificity of 10s to 100s of antibody candidates during your discovery campaign to inform triaging&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#x52;||divi||400&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;d248538e-e1ae-493e-b38e-1f4c5e8a6e82&#8243; header_font=&#8221;Urbanist|&#8211;et_global_heading_font_weight|||||||&#8221; header_text_color=&#8221;#1A283B&#8221; background_layout=&#8221;dark&#8221; custom_padding=&#8221;|||30px|false|false&#8221; header_font_size_tablet=&#8221;&#8221; header_font_size_phone=&#8221;&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{%22gcid-1f1b4e15-7cc6-4e13-8154-74d77a956460%22:%91%22icon_color%22%93}&#8221;][\/et_pb_blurb][et_pb_blurb title=&#8221;Only small amounts (50 micrograms) of antibody required&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#x52;||divi||400&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;d248538e-e1ae-493e-b38e-1f4c5e8a6e82&#8243; header_font=&#8221;Urbanist|&#8211;et_global_heading_font_weight|||||||&#8221; header_text_color=&#8221;#1A283B&#8221; background_layout=&#8221;dark&#8221; custom_padding=&#8221;|||30px|false|false&#8221; header_font_size_tablet=&#8221;&#8221; header_font_size_phone=&#8221;&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{%22gcid-1f1b4e15-7cc6-4e13-8154-74d77a956460%22:%91%22icon_color%22%93}&#8221;][\/et_pb_blurb][et_pb_image src=&#8221;https:\/\/ectocellect.com\/wp-content\/uploads\/2024\/11\/Ectocellect_rationale-1-scaled.jpg&#8221; title_text=&#8221;Ectocellect_rationale (1)&#8221; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; border_radii=&#8221;on|17px|17px|17px|17px&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_3,2_3&#8243; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; max_width=&#8221;1500px&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/ectocellect.com\/wp-content\/uploads\/2025\/11\/case-study-1.png&#8221; title_text=&#8221;case-study-1&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;Case Study 1&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;af177d2f-91a8-4f2e-87ba-17a4fb97b9b4&#8243; title_text_align=&#8221;left&#8221; title_font_size=&#8221;25px&#8221; custom_margin=&#8221;||10px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;707627bc-2994-4635-8ae1-9f0e8da7cbac&#8221; custom_margin=&#8221;||17px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span style=\"font-weight: 400;\">Camerilzumab (SHR-1210) is an anti-PD1 antibody that has known off-target binding to VEGFR and ULBP2 which were identified on the Ectocellect array. Camrelizumab is formatted as an IgG4.<\/span><\/p>\n<p>[\/et_pb_text][et_pb_button button_url=&#8221;https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6343799&#8243; url_new_window=&#8221;on&#8221; button_text=&#8221;Read More&#8221; button_alignment=&#8221;left&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_text_color=&#8221;#1a283b&#8221; button_border_width=&#8221;1px&#8221; button_border_radius=&#8221;38px&#8221; button_font=&#8221;Urbanist||||||||&#8221; button_icon=&#8221;&#x3d;||divi||400&#8243; button_on_hover=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; max_width=&#8221;1500px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;|||30px|false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/ectocellect.com\/wp-content\/uploads\/2025\/11\/Camrelizumab.jpg&#8221; title_text=&#8221;Camrelizumab&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;|30px|||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;Case Study 1&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;af177d2f-91a8-4f2e-87ba-17a4fb97b9b4&#8243; title_text_align=&#8221;left&#8221; title_font_size=&#8221;25px&#8221; custom_margin=&#8221;||10px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;707627bc-2994-4635-8ae1-9f0e8da7cbac&#8221; custom_margin=&#8221;||17px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span style=\"font-weight: 400;\">Camerilzumab (SHR-1210) is an anti-PD1 antibody that has known off-target binding to VEGFR and ULBP2 which were identified on the Ectocellect array. Camrelizumab is formatted as an IgG4.<\/span><\/p>\n<p>[\/et_pb_text][et_pb_button button_url=&#8221;https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6343799&#8243; url_new_window=&#8221;on&#8221; button_text=&#8221;Read More&#8221; button_alignment=&#8221;left&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_text_color=&#8221;#1a283b&#8221; button_border_width=&#8221;1px&#8221; button_border_radius=&#8221;38px&#8221; button_font=&#8221;Urbanist||||||||&#8221; button_icon=&#8221;&#x3d;||divi||400&#8243; button_on_hover=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,2_3&#8243; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; max_width=&#8221;1500px&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/ectocellect.com\/wp-content\/uploads\/2025\/11\/Case-Study-2.png&#8221; title_text=&#8221;Case-Study-2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;Case Study 2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;af177d2f-91a8-4f2e-87ba-17a4fb97b9b4&#8243; title_text_align=&#8221;left&#8221; title_font_size=&#8221;25px&#8221; custom_margin=&#8221;||10px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;707627bc-2994-4635-8ae1-9f0e8da7cbac&#8221; custom_margin=&#8221;||17px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span style=\"font-weight: 400;\">An IgG1-formatted anti-PD-L1 antibody was shown to have no detectable off-target binding on the Ectocellect array. As well as the PD-L1 target, the IgG1 antibody Fc receptors were identified. <\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; max_width=&#8221;1500px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;|||30px|false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/ectocellect.com\/wp-content\/uploads\/2025\/11\/AntiPDL1_arrows.jpg&#8221; title_text=&#8221;AntiPDL1_arrows&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;|30px|||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;Case Study 2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;af177d2f-91a8-4f2e-87ba-17a4fb97b9b4&#8243; title_text_align=&#8221;left&#8221; title_font_size=&#8221;25px&#8221; custom_margin=&#8221;||10px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;707627bc-2994-4635-8ae1-9f0e8da7cbac&#8221; custom_margin=&#8221;||17px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span style=\"font-weight: 400;\">An IgG1-formatted anti-PD-L1 antibody was shown to have no detectable off-target binding on the Ectocellect array. As well as the PD-L1 target, the IgG1 antibody Fc receptors were identified. <\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Features&#8221; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;305b1d93-998f-4d0b-9707-229bb54ee3bc&#8221; background_color=&#8221;gcid-ce695d38-7b45-4ff3-bae8-e54df8b6593b&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{%22gcid-ce695d38-7b45-4ff3-bae8-e54df8b6593b%22:%91%22background_color%22%93}&#8221;][et_pb_row _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;Essential Features for Reliable Antibody Screening&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;af177d2f-91a8-4f2e-87ba-17a4fb97b9b4&#8243; title_text_align=&#8221;center&#8221; custom_margin=&#8221;||10px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_blurb title=&#8221;High-Quality Human Receptor Arrays&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#xf610;||fa||900&#8243; icon_color=&#8221;#1a283b&#8221; icon_alignment=&#8221;center&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;01974b2a-1040-444a-8a83-78ee5b574e09&#8243; header_text_color=&#8221;#1A283B&#8221; body_text_color=&#8221;#1A283B&#8221; background_color=&#8221;#FFFFFF&#8221; text_orientation=&#8221;center&#8221; border_width_all=&#8221;3px&#8221; border_color_all=&#8221;#1A283B&#8221; global_colors_info=&#8221;{%22gcid-d7cd5a78-aaef-4f36-82a3-4d3706015cba%22:%91%22link_text_color%22,%22link_text_color%22,%22link_text_color%22%93,%22gcid-1f1b4e15-7cc6-4e13-8154-74d77a956460%22:%91%22link_text_color%22,%22quote_text_color%22,%22quote_border_color%22,%22link_text_color%22,%22quote_text_color%22,%22quote_border_color%22%93}&#8221;]<\/p>\n<p>Test against validated human receptor ectodomains expressed in human cells, ensuring real-world relevance.<\/p>\n<p>[\/et_pb_blurb][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_blurb title=&#8221;Proactive Off-Target Detection&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#xf3ed;||fa||900&#8243; icon_color=&#8221;#1A283B&#8221; image_icon_background_color=&#8221;#FFFFFF&#8221; icon_alignment=&#8221;center&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;01974b2a-1040-444a-8a83-78ee5b574e09&#8243; header_text_color=&#8221;#1A283B&#8221; body_text_color=&#8221;#1A283B&#8221; background_color=&#8221;#FFFFFF&#8221; text_orientation=&#8221;center&#8221; border_width_all=&#8221;3px&#8221; border_color_all=&#8221;#1A283B&#8221; border_color_all_image=&#8221;#1A283B&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{%22gcid-d7cd5a78-aaef-4f36-82a3-4d3706015cba%22:%91%22link_text_color%22,%22link_text_color%22,%22link_text_color%22%93,%22gcid-1f1b4e15-7cc6-4e13-8154-74d77a956460%22:%91%22link_text_color%22,%22quote_text_color%22,%22quote_border_color%22,%22link_text_color%22,%22quote_text_color%22,%22quote_border_color%22,%22link_text_color%22,%22quote_text_color%22,%22quote_border_color%22%93}&#8221; border_color_all__hover_enabled=&#8221;on|desktop&#8221; border_color_all__hover=&#8221;#1A283B&#8221;]<\/p>\n<p>Identify potential off-target interactions early, minimising costly failures and enhancing clinical trial readiness.<\/p>\n<p>[\/et_pb_blurb][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_blurb title=&#8221;Cost-Effective, Scalable Testing&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#xf51e;||fa||900&#8243; icon_color=&#8221;#1A283B&#8221; icon_alignment=&#8221;center&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;01974b2a-1040-444a-8a83-78ee5b574e09&#8243; header_text_color=&#8221;#1A283B&#8221; body_text_color=&#8221;#1A283B&#8221; background_color=&#8221;#FFFFFF&#8221; text_orientation=&#8221;center&#8221; border_width_all=&#8221;3px&#8221; border_color_all=&#8221;#1A283B&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Our platform provides scalable testing solutions, making it feasible to screen a high number of leads efficiently.<\/p>\n<p>[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Programs&#8221; module_id=&#8221;Applications&#8221; _builder_version=&#8221;4.27.2&#8243; _module_preset=&#8221;5a41550e-bb41-40cd-9402-2df3cc893f5b&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.27.2&#8243; _module_preset=&#8221;default&#8221; width=&#8221;89%&#8221; max_width=&#8221;1725px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;Applications&#8221; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;aa0ff2c6-4749-426d-995f-6fa158faee8c&#8221; title_text_color=&#8221;gcid-1f1b4e15-7cc6-4e13-8154-74d77a956460&#8243; custom_margin=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{%22gcid-1f1b4e15-7cc6-4e13-8154-74d77a956460%22:%91%22title_text_color%22%93}&#8221;][\/et_pb_heading][et_pb_heading title=&#8221;Boost your research using the Ectocellect receptor array for:&#8221; _builder_version=&#8221;4.27.2&#8243; _module_preset=&#8221;eba291d1-c66f-4390-936e-45a349798898&#8243; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; width=&#8221;89%&#8221; max_width=&#8221;1686px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/ectocellect.com\/wp-content\/uploads\/2025\/10\/Application-2-1.jpg&#8221; title_text=&#8221;Application-2&#8243; url=&#8221;https:\/\/ectocellect.com\/?page_id=125&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;922a35c2-e5b8-45c9-b5a1-02911cedc9fe&#8221; min_height=&#8221;155.8px&#8221; custom_margin=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_heading title=&#8221;Antibody target deconvolution  &#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;592518e2-95a0-450f-8009-699fb1693990&#8243; custom_margin=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;707627bc-2994-4635-8ae1-9f0e8da7cbac&#8221; custom_margin=&#8221;||17px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Identify the targets of functional antibodies of unknown specificity.<\/p>\n<p>[\/et_pb_text][et_pb_button button_url=&#8221;@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjEyNSJ9fQ==@&#8221; button_text=&#8221;Learn More&#8221; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.27.4&#8243; _dynamic_attributes=&#8221;button_url&#8221; _module_preset=&#8221;dfb0e518-2979-485c-8b06-b5f2606a4bbd&#8221; custom_padding=&#8221;14px|50px|14px|40px|true|false&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/ectocellect.com\/wp-content\/uploads\/2025\/10\/Receptor-deorphanisation-1.jpg&#8221; title_text=&#8221;Receptor-deorphanisation&#8221; url=&#8221;https:\/\/ectocellect.com\/?page_id=116&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;922a35c2-e5b8-45c9-b5a1-02911cedc9fe&#8221; min_height=&#8221;199.9px&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;||0px|||&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_heading title=&#8221;Receptor deorphanisation &#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;592518e2-95a0-450f-8009-699fb1693990&#8243; custom_margin=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;707627bc-2994-4635-8ae1-9f0e8da7cbac&#8221; custom_margin=&#8221;||17px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Discover new receptors and ligands.<\/p>\n<p>[\/et_pb_text][et_pb_button button_url=&#8221;@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjExNiJ9fQ==@&#8221; button_text=&#8221;Learn More&#8221; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.27.4&#8243; _dynamic_attributes=&#8221;button_url&#8221; _module_preset=&#8221;dfb0e518-2979-485c-8b06-b5f2606a4bbd&#8221; custom_padding=&#8221;14px|50px|14px|40px|true|false&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/ectocellect.com\/wp-content\/uploads\/2025\/10\/Autoantibody-target-discovery-1.jpg&#8221; title_text=&#8221;Autoantibody-target-discovery&#8221; url=&#8221;https:\/\/ectocellect.com\/?page_id=273&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;922a35c2-e5b8-45c9-b5a1-02911cedc9fe&#8221; custom_margin=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_heading title=&#8221;Autoantibody target discovery &#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;592518e2-95a0-450f-8009-699fb1693990&#8243; custom_margin=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;707627bc-2994-4635-8ae1-9f0e8da7cbac&#8221; custom_margin=&#8221;||10px||false|false&#8221; custom_padding=&#8221;||5px|||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Discover the targets of patient autoantibodies.<\/p>\n<p>[\/et_pb_text][et_pb_button button_url=&#8221;@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI3MyJ9fQ==@&#8221; button_text=&#8221;Learn More&#8221; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.27.4&#8243; _dynamic_attributes=&#8221;button_url&#8221; _module_preset=&#8221;dfb0e518-2979-485c-8b06-b5f2606a4bbd&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Footer&#8221; module_id=&#8221;Contact&#8221; _builder_version=&#8221;4.27.2&#8243; _module_preset=&#8221;a41791f7-5e59-44e5-ab7e-f0e840e3570f&#8221; saved_tabs=&#8221;all&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50Ijoic2l0ZV9sb2dvIiwic2V0dGluZ3MiOnt9fQ==@&#8221; title_text=&#8221;divi-logo-mark-white&#8221; url=&#8221;@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoiaG9tZV91cmwiLCJzZXR0aW5ncyI6e319@&#8221; _builder_version=&#8221;4.25.2&#8243; _dynamic_attributes=&#8221;src,url&#8221; _module_preset=&#8221;default&#8221; max_height=&#8221;64px&#8221; custom_margin=&#8221;||20px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.27.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.27.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;Get in touch for a personalised consultation&#8221; _builder_version=&#8221;4.27.2&#8243; _module_preset=&#8221;e42f8f87-2a59-4c9a-82d2-564c739f0921&#8243; title_text_align=&#8221;left&#8221; title_text_color=&#8221;#FFFFFF&#8221; title_font_size=&#8221;58px&#8221; custom_margin=&#8221;||10px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.27.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_contact_form email=&#8221;kabir.khan@york.ac.uk, gavin.wright@york.ac.uk, cliodhna@brilliantred.co.uk&#8221; custom_message=&#8221;%%Name%%||et_pb_line_break_holder||%%Email%%||et_pb_line_break_holder||%%Message%%&#8221; _builder_version=&#8221;4.27.6&#8243; _module_preset=&#8221;default&#8221; _unique_id=&#8221;4a21cd6d-9f2d-4af0-a381-92ddc50f5ee9&#8243; form_field_background_color=&#8221;RGBA(255,255,255,0)&#8221; form_field_text_color=&#8221;#FFFFFF&#8221; captcha_text_color=&#8221;#FFFFFF&#8221; captcha_letter_spacing=&#8221;10px&#8221; custom_button=&#8221;on&#8221; button_text_color=&#8221;#FFFFFF&#8221; button_border_radius=&#8221;32px&#8221; hover_enabled=&#8221;0&#8243; border_radii=&#8221;on|18px|18px|18px|18px&#8221; border_width_all=&#8221;1px&#8221; border_color_all=&#8221;#FFFFFF&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][et_pb_contact_field field_id=&#8221;Name&#8221; field_title=&#8221;Name&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221; button_text_size__hover_enabled=&#8221;off&#8221; button_one_text_size__hover_enabled=&#8221;off&#8221; button_two_text_size__hover_enabled=&#8221;off&#8221; button_text_color__hover_enabled=&#8221;off&#8221; button_one_text_color__hover_enabled=&#8221;off&#8221; button_two_text_color__hover_enabled=&#8221;off&#8221; button_border_width__hover_enabled=&#8221;off&#8221; button_one_border_width__hover_enabled=&#8221;off&#8221; button_two_border_width__hover_enabled=&#8221;off&#8221; button_border_color__hover_enabled=&#8221;off&#8221; button_one_border_color__hover_enabled=&#8221;off&#8221; button_two_border_color__hover_enabled=&#8221;off&#8221; button_border_radius__hover_enabled=&#8221;off&#8221; button_one_border_radius__hover_enabled=&#8221;off&#8221; button_two_border_radius__hover_enabled=&#8221;off&#8221; button_letter_spacing__hover_enabled=&#8221;off&#8221; button_one_letter_spacing__hover_enabled=&#8221;off&#8221; button_two_letter_spacing__hover_enabled=&#8221;off&#8221; button_bg_color__hover_enabled=&#8221;off&#8221; button_one_bg_color__hover_enabled=&#8221;off&#8221; button_two_bg_color__hover_enabled=&#8221;off&#8221;][\/et_pb_contact_field][et_pb_contact_field field_id=&#8221;Email&#8221; field_title=&#8221;Email Address&#8221; field_type=&#8221;email&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221; button_text_size__hover_enabled=&#8221;off&#8221; button_one_text_size__hover_enabled=&#8221;off&#8221; button_two_text_size__hover_enabled=&#8221;off&#8221; button_text_color__hover_enabled=&#8221;off&#8221; button_one_text_color__hover_enabled=&#8221;off&#8221; button_two_text_color__hover_enabled=&#8221;off&#8221; button_border_width__hover_enabled=&#8221;off&#8221; button_one_border_width__hover_enabled=&#8221;off&#8221; button_two_border_width__hover_enabled=&#8221;off&#8221; button_border_color__hover_enabled=&#8221;off&#8221; button_one_border_color__hover_enabled=&#8221;off&#8221; button_two_border_color__hover_enabled=&#8221;off&#8221; button_border_radius__hover_enabled=&#8221;off&#8221; button_one_border_radius__hover_enabled=&#8221;off&#8221; button_two_border_radius__hover_enabled=&#8221;off&#8221; button_letter_spacing__hover_enabled=&#8221;off&#8221; button_one_letter_spacing__hover_enabled=&#8221;off&#8221; button_two_letter_spacing__hover_enabled=&#8221;off&#8221; button_bg_color__hover_enabled=&#8221;off&#8221; button_one_bg_color__hover_enabled=&#8221;off&#8221; button_two_bg_color__hover_enabled=&#8221;off&#8221;][\/et_pb_contact_field][et_pb_contact_field field_id=&#8221;Message&#8221; field_title=&#8221;Message&#8221; field_type=&#8221;text&#8221; fullwidth_field=&#8221;on&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221; button_text_size__hover_enabled=&#8221;off&#8221; button_one_text_size__hover_enabled=&#8221;off&#8221; button_two_text_size__hover_enabled=&#8221;off&#8221; button_text_color__hover_enabled=&#8221;off&#8221; button_one_text_color__hover_enabled=&#8221;off&#8221; button_two_text_color__hover_enabled=&#8221;off&#8221; button_border_width__hover_enabled=&#8221;off&#8221; button_one_border_width__hover_enabled=&#8221;off&#8221; button_two_border_width__hover_enabled=&#8221;off&#8221; button_border_color__hover_enabled=&#8221;off&#8221; button_one_border_color__hover_enabled=&#8221;off&#8221; button_two_border_color__hover_enabled=&#8221;off&#8221; button_border_radius__hover_enabled=&#8221;off&#8221; button_one_border_radius__hover_enabled=&#8221;off&#8221; button_two_border_radius__hover_enabled=&#8221;off&#8221; button_letter_spacing__hover_enabled=&#8221;off&#8221; button_one_letter_spacing__hover_enabled=&#8221;off&#8221; button_two_letter_spacing__hover_enabled=&#8221;off&#8221; button_bg_color__hover_enabled=&#8221;off&#8221; button_one_bg_color__hover_enabled=&#8221;off&#8221; button_two_bg_color__hover_enabled=&#8221;off&#8221;][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Up to a third of all lead candidate antibodies display off-target binding: Read MoreCamerilzumab (SHR-1210) is an anti-PD1 antibody that has known off-target binding to VEGFR and ULBP2 which were identified on the Ectocellect array. Camrelizumab is formatted as an IgG4.Camerilzumab (SHR-1210) is an anti-PD1 antibody that has known off-target binding to VEGFR and ULBP2 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-97","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/ectocellect.com\/index.php?rest_route=\/wp\/v2\/pages\/97","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ectocellect.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ectocellect.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ectocellect.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ectocellect.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=97"}],"version-history":[{"count":39,"href":"https:\/\/ectocellect.com\/index.php?rest_route=\/wp\/v2\/pages\/97\/revisions"}],"predecessor-version":[{"id":448,"href":"https:\/\/ectocellect.com\/index.php?rest_route=\/wp\/v2\/pages\/97\/revisions\/448"}],"wp:attachment":[{"href":"https:\/\/ectocellect.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=97"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}