The Ectocellect human cell surface receptor discovery platform
Quantify antibody binding specificity and discover extracellular protein interactions in a scalable, cost-effective, format
Our Technology
Our technology consists of a high-quality genome-scale human protein array containing functional receptor ectodomains. The design of each ectodomain is hand curated accounting for its structural architecture including type I and type II membrane proteins, homodimers, and heterodimers. Each protein is individually expressed, purified, quality checked, and normalised before orientated immobilisation leading to low false negatives.
Applications
- Specificity testing of candidates therapeutic antibodies, including chimeric antibodies, CARs, nanobodies etc
- Validation of affinity binders generated by AI structural modelling
- Identifying the targets of antibodies of unknown binding specificity
- Discovering targets of idiopathic antibody-based autoimmunity
- Identifying receptors for orphan ligands
Applications
Boost your research using the Ectocellect receptor array for:
Therapeutic antibody specificity testing
Cost effectively test binding specificity of antibodies for AI-designed binders.
Antibody target deconvolution
Identify the targets of functional antibodies of unknown specificity.
Receptor deorphanisation
Discover new receptors and ligands.
Autoantibody target discovery
Discover the targets of patient autoantibodies.
