Receptor Discovery and Deorphanization
Extracellular interactions involving membrane-embedded proteins are challenging to identify because:
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Membrane proteins are difficult to solubilise
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Interactions are typically of low affinity (half lives < 1sec) and so cannot withstand washing steps.
The Ectocellect platform is normalised and validated array of > 1500 functional human receptor ectodomains.
Screening assays are able to detect even very weak interactions with low false positive and false negative rates
A trusted platform to deorphanize ligands and receptors
Host-pathogen interactions including virus receptors, microbiome, and parasites
